Research progress on the strategy and mechanism of sonodynamic immunotherapy
10.3760/cma.j.cn131148-20241211-00642
- VernacularTitle:声动力免疫治疗策略与机制的研究进展
- Author:
Zesheng LI
1
;
Beibei ZHANG
;
Shaobo DUAN
;
Ruiqing LIU
;
Yaqiong LI
;
Yuzhou WANG
;
Rong HUANG
;
Lianzhong ZHANG
Author Information
1. 郑州大学人民医院，河南省人民医院超声科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Sonodynamic therapy;
Immunotherapy;
Immunogenic cell death;
Immune checkpoint blockade
- From:
Chinese Journal of Ultrasonography
2025;34(4):357-363
- CountryChina
- Language:Chinese
-
Abstract:
Sonodynamic therapy（SDT）has garnered significant attention in cancer treatment modalities due to its superior tissue penetration capabilities，non-invasive approach，and controllability. SDT operates by utilizing sonosensitizers and ultrasound-responsive devices to induce the production of reactive oxygen species（ROS）under ultrasound stimulation，thereby eliciting immunogenic cell death（ICD）in tumor cells and the release of damage-associated molecular patterns，which in turn trigger an immune response against the tumor.However，the tumor microenvironment often results in a relatively weak immune response post-cancer treatment. To address this issue，extensive research is being conducted on combining SDT with immunotherapy，particularly focusing on immune checkpoint blockade（ICB）therapies. This review synthesizes the mechanisms of SDT，its integration with immunotherapy，especially ICB therapies，and the current state of research，with the objective of providing strategic guidance for the advancement of sonodynamic immunotherapy.
