Research progress on the correlation between insulin resistance and cerebral microbleeds
10.3760/cma.j.cn113694-20241128-00767
- VernacularTitle:胰岛素抵抗与脑微出血相关性的研究进展
- Author:
Chaojuan HUANG
1
;
Xia ZHOU
;
Yimei ZHANG
;
Jie GENG
;
Xiaoqun ZHU
;
Zhongwu SUN
Author Information
1. 安徽医科大学第一附属医院神经内科，合肥 230022
- Publication Type:Journal Article
- Keywords:
Cerebral amyloid angiopathy;
Cerebral small vessel disease;
Cerebral microbleed;
Insulin resistance;
Hypertensive arteriopathy
- From:
Chinese Journal of Neurology
2025;58(6):658-664
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease (CSVD) is a leading cause of stroke and vascular cognitive impairment, with cerebral microbleeds (CMB) recognized as one of its key imaging biomarkers. The pathological mechanisms underlying CMB vary significantly depending on their anatomical location. In recent years, insulin resistance (IR), a hallmark of metabolic syndrome, has emerged as a critical area of research in understanding the pathogenesis of CMB. This review focuses on the following aspects: an overview of the pathophysiological mechanisms of CMB and their location-specific characteristics; a detailed discussion of the definition of IR and its clinical research advancements in relation to CMB; and a comprehensive analysis of the potential pathways through which IR contributes to CMB development, including exacerbation of amyloid-beta pathology, activation of the renin-angiotensin and sympathetic nervous systems, induction of inflammation and oxidative stress, and disruption of the blood-brain barrier. The evidence highlights that IR exerts both specific and shared effects on different types of CMB, offering valuable insights for the early detection, targeted intervention, and holistic management of CSVD.
