Symptom management and immunotherapy in severe autoimmune encephalitis: challenges and prospects
10.3760/cma.j.cn113694-20250116-00036
- VernacularTitle:重症自身免疫性脑炎的症状管理及免疫治疗：挑战与展望
- Author:
Bingjun ZHANG
1
;
Han CAI
1
;
Zhengqi LU
1
Author Information
1. 中山大学附属第三医院神经内科，精神与神经疾病研究中心，广州510630
- Publication Type:Journal Article
- Keywords:
Encephalitis;
Autoimmune diseases of the nervous system;
Intensive care;
Symptom management;
Immunotherapy
- From:
Chinese Journal of Neurology
2025;58(7):680-686
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune encephalitis is a type of encephalitis mediated by autoimmune mechanisms, with more than half of the patients requiring intensive care due to consciousness disorder, severe movement disorders, autonomic dysfunction, and status epilepticus. In the early stages, the symptoms of autoimmune encephalitis are varied, including cognitive decline, memory impairments, behavioral changes, movement disorders, and seizures. Without timely and appropriate treatment, it may progress into severe autoimmune encephalitis (SAE) due to challenges in early recognition. Early diagnosis and prompt immunotherapy are crucial for determining the prognosis. The current research evidence and related guidelines, discussing aspects such as symptom management, complication management, and immunotherapy strategies for SAE patients were summarized in this article, with the aim of providing effective references for clinical practice.
