Antibody-drug conjugates associated peripheral neuropathy: report of 3 cases

VernacularTitle:抗体-药物偶联物相关周围神经病3例
Author: Deshun XIONG ¹ ; Sen LIU ; Hua CHEN ; Ying PU ; Yukun GUO ; Heng LI
Author Information

1. 山东大学齐鲁医学院，济南　250012
Publication Type:Journal Article
Keywords: Antineoplastic agents; Tubulin; Peripheral nervous system diseases; Antibody-drug conjugates
From: Chinese Journal of Neurology 2025;58(2):179-183
CountryChina
Language:Chinese
Abstract: Antibody-drug conjugates (ADC) are one of the most popular types of anti-tumor drugs nowadays. Monomethyl auristatin E (MMAE), as a tubulin binder, is the most common applied payload in ADC and is also the main component that causes peripheral neuropathy (PN). By describing the clinical characteristics of 3 cases with MMAE ADC associated severe PN complications and analyzing reported references, this article summarizes that the occurrence of MMAE ADC associated PN is correlated with therapeutic cycles and duration of ADC, MMAE ADC associated PN is different from traditional chemotherapy-induced PN in the clinical presentation. Patients with MMAE ADC associated PN may present with a length-dependent involvement of peripheral motor and sensory nerves, and generally their weakness and deep sensory deficiency symptoms are more serious compared with traditional chemotherapy-induced PN. Two of the 3 patients achieved a relatively rapid recovery after treated with plasma exchange or immunoglobulin intravenous infusions.