Characteristics of cognitive function and related influencing factors in Parkinson′s disease patients with or without olfactory anosognosia
10.3760/cma.j.cn113694-20240918-00623
- VernacularTitle:帕金森病伴或不伴嗅觉病感缺失患者的认知功能特点及相关影响因素分析
- Author:
Mengyuan TU
1
;
Yanqiu WEI
1
;
Yimeng CHEN
1
;
Hongyao DUAN
1
;
Jingfang RONG
1
;
Zhanming MA
1
;
Jiangbing LIU
1
Author Information
1. 扬州大学附属医院神经内科，扬州 225000
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Olfaction disorders;
Cognitive dysfunction
- From:
Chinese Journal of Neurology
2025;58(5):506-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the cognitive characteristics and related influencing factors in Parkinson′s disease (PD) patients with or without olfactory anosognosia (OA).Methods:A total of 113 PD patients who were treated at the Affiliated Hospital of Yangzhou University between March 2023 and April 2024 were selected. The PD Olfactory Dysfunction Auxiliary Diagnostic Card was used to assess olfactory function. Based on the olfactory identification scores and subjective awareness of olfactory dysfunction, patients were divided into the normosmic group, olfactory dysfunction group, and the later was further divided into olfactory dysfunction without OA (OA-) group, and olfactory dysfunction with OA (OA+) group. The results of the Unified Parkinson′s Disease Rating Scale-Ⅲ (UPDRS-Ⅲ) and Hoehn-Yahr (H-Y) staging assessments of the patients were collected. Non-motor symptoms such as cognitive function, anxiety, depression, sleep disturbances, and constipation were evaluated using relevant scales. Logistic regression analysis was used to explore the related factors affecting OA in PD patients with olfactory decline.Results:The Montreal Cognitive Assessment (MoCA) scores of the olfactory dysfunction group were lower than those of the normosmic group (20.30±4.47 vs 22.64±2.50, t=2.907, P=0.007). The Self-Rating Anxiety Scale scores (39.00±8.60 vs 43.86±10.63, t=2.444, P=0.016), visuospatial and executive function scores (2.35±1.32 vs 2.98±1.42, t=2.263, P=0.026), and orientation scores (4.88±1.14 vs 5.34±1.07, t=2.046, P=0.043) of the OA+ group were lower than those of the OA- group. Logistic regression analysis revealed that lower MoCA scores were an independent risk factor for PD combined with OA ( OR=0.853, 95% CI 0.743-0.980, P=0.024). Conclusions:PD patients with olfactory dysfunction exhibit more severe cognitive impairment. Among them, patients with OA show more significant impairments in visuospatial, executive function and orientation. Cognitive impairment may be an independent risk factor for PD combined with OA.
