Cerebral syphilitic gumma misdiagnosed as multicentric glioma: a case report
10.3760/cma.j.cn113694-20240704-00457
- VernacularTitle:误诊为多中心胶质瘤的树胶肿型神经梅毒1例
- Author:
Kun HU
1
;
Xin XIANG
;
Zhongqi QI
;
Zhengyang LI
;
Chenglian XUE
;
Linyu HUO
;
Ziyan ZHANG
;
Yuan GAO
;
Jidian SUN
;
Fenghui SUN
Author Information
1. 首都医科大学附属北京佑安医院神经内科，北京 100069
- Publication Type:Journal Article
- Keywords:
Neurosyphilis;
Cerebral syphilitic gumma;
Multicentric glioma;
Granulomatous inflammation
- From:
Chinese Journal of Neurology
2025;58(4):419-425
- CountryChina
- Language:Chinese
-
Abstract:
Neurosyphilis is a group of clinical syndromes caused by treponema pallidum invading the central nervous system and causing varying degrees of damage to the brain parenchyma, brain (spinal) membrane or spinal cord. Cerebral syphilitic gumma is the rarest form of neurosyphilis, and its clinical manifestations lack specificity, which is easily confused with other intracranial space occupying lesions on imaging. In this article, a patient with cognitive dysfunction, intracranial hypertension, and imaging findings similar to multicentric glioma was diagnosed as cerebral syphilitic gumma by serology, cerebrospinal fluid test and brain histopathology. The symptoms basically disappeared after treatment with standard penicillin. This report aims to raise awareness of cerebral syphilitic gumma in order to reduce missed diagnosis and misdiagnosis.
