Advances in arrhythmia-associated autoantibodies
10.3760/cma.j.cn114452-20250520-00299
- VernacularTitle:心律失常相关自身抗体的研究进展
- Author:
Danyu SONG
1
;
Yang ZHANG
1
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 实验诊断中心，北京 100037
- Publication Type:Journal Article
- Keywords:
Arrhythmias, cardiac;
Autoantibodies;
Autoimmunity
- From:
Chinese Journal of Laboratory Medicine
2025;48(11):1478-1484
- CountryChina
- Language:Chinese
-
Abstract:
Arrhythmia refers to abnormal heart rhythms or frequencies caused by disturbances in the origin and/or conduction of cardiac electrical activity. Arrhythmias are generally considered to be caused by organic heart disease, yet the etiology of some arrhythmias remains unknown. In recent years, extensive studies have focused on the role of cardiac autoantibodies in the pathogenesis and progression of arrhythmias. Cardiac autoantibodies targeting cardiac receptors and ion channels contribute to arrhythmogenesis by inducing cardiac structural remodeling and electrophysiological disturbances. Various arrhythmias, including atrial fibrillation, heart block, long QT syndrome, short QT syndrome, and Brugada syndrome, have been confirmed to be associated with autoantibodies. This article will provide a comprehensive summary of the latest research advancements and clinical implications of arrhythmia-related autoantibodies.
