Initial clinical experience with the perceval sutureless aortic valve: insights from a single center
10.3760/cma.j.cn112434-20250325-00093
- VernacularTitle:Perceval免缝合主动脉瓣的早期临床疗效：单中心经验
- Author:
Tong TAN
1
;
Yongqiang LAI
1
;
Jiangang WANG
1
;
Xiubin YANG
1
;
Ran DONG
1
;
Hao CUI
1
;
Enjun ZHU
1
;
Hongchang GUO
1
Author Information
1. 北京市心肺血管疾病研究所 首都医科大学附属北京安贞医院心脏外科，北京 100029
- Publication Type:Journal Article
- Keywords:
Aortic valve replacement;
Sutureless prostheses;
Sutureless aortic valve replacement;
Clinical outcomes
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2025;41(10):624-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the early clinical outcomes of aortic valve replacement(AVR) using the Perceval sutureless aortic valve.Methods:This retrospective study included 50 patients who underwent AVR with the Perceval sutureless prostheses at Beijing Anzhen Hospital between June 2023 and January 2025. Surgical parameters, early clinical outcomes, valve function, and hemodynamic performance were evaluated to summarize clinical effectiveness.Results:The mean age of patients was(63.5±9.1) years, predominantly female(36/50). Severe aortic stenosis was present in 43 cases(86.0%). A preoperative aortic annulus dimension of 20.0(19.0, 21.0) mm measured in both anteroposterior and transverse diameters. Preoperative peak transvalvular gradient was(92.7±31.0)mmHg(1 mmHg=0.133 kPa), with a mean gradient of (58.0±21.2) mmHg. All procedures were successfully completed using the Perceval sutureless prostheses. Isolated AVR was performed in 20 patients(40.0%), with cardiopulmonary bypass and aortic cross-clamp times of 75.0(50.5, 99.5) min and 50.5(29.5, 71.5) min, respectively. Postoperative transesophageal echocardiography revealed an immediate reduction in the peak transvalvular gradient to 11.0(8.0, 18.0) mmHg, significantly lower compared to preoperative measurements( P<0.001). Two cases of paravalvular leakage and one case requiring permanent pacemaker implantation were reported postoperatively. All patients completed the 3-month follow-up, with one death during the follow-up period; the remaining patients exhibited normal prosthetic valve function without major adverse cardiovascular events. Significant postoperative reductions were observed in left ventricular end-diastolic diameter(45.8 mm vs. 43.2 mm, P=0.003) and left atrial diameter(53.9 mm vs. 44.6 mm, P<0.001) compared with baseline. Conclusion:AVR using the Perceval sutureless prostheses demonstrated safe and effective early clinical outcomes with excellent hemodynamic performance and low incidence of postoperative paravalvular leakage and permanent pacemaker implantation. The sutureless technique represents a viable alternative strategy, particularly advantageous for patients with small aortic annuli or complex surgical conditions, warranting broader clinical adoption.
