Post-transplant parvovirus B19 infection and diagnostic research progress
10.3760/cma.j.cn114452-20240809-00442
- VernacularTitle:移植后人细小病毒B19感染及诊断研究进展
- Author:
Ya′nan ZHAO
1
;
Zhen SONG
;
Yuze ZHU
;
Qingtian LI
;
Hui LI
;
Beiwen WEI
;
Jiewen HUANG
;
Juanxiu QIN
;
Min LI
Author Information
1. 上海交通大学医学院医学技术学院医学检验技术系，上海 200025
- Publication Type:Journal Article
- Keywords:
Transplantation;
Human parvovirus B19;
Testing;
Serology;
Molecular Biology
- From:
Chinese Journal of Laboratory Medicine
2025;48(3):412-418
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is an effective treatment for end-stage organ failure, but postoperative infections and rejection reactions are key factors affecting the survival of the patients. Recently, the incidence of human parvovirus B19 (B19V) infection following transplantation has increased. B19V is a non-enveloped virus that primarily infects the upper respiratory tract and exhibits significant tropism for erythroid progenitor cells in the bone marrow, leading to the lysis of erythrocytes and hematological abnormalities. After B19V viremia, it may further infect other cells, triggering inflammatory responses and tissue damage. B19V infection may lead to chronic anemia in organ transplant patients, thereby affecting the success of the transplant and the survival of the patients. Therefore, it is essential to diagnose and monitor B19V infection post-transplantation. Due to the immunosuppressive therapy following transplantation, traditional serological detection methods, such as IgM and IgG antibody tests, are often unreliable. In contrast, molecular biological detection, especially real-time fluorescent quantitative PCR technology, provides more accurate results. However, the diversity of B19V genotypes may lead to the missed detection of some genotypes. Thus, it is necessary to use different detection techniques to improve the diagnostic accuracy of B19 virus infections. Additionally, there is a need to explore more precise diagnostic methods to enhance the early identification and management of B19V infection, further improving the survival and life quality of the patients.
