Predicting value of intestinal fatty acid-binding protein in esophageal varices in patients with hepatitis B cirrhosis
10.3760/cma.j.cn114452-20250206-00057
- VernacularTitle:肠型脂肪酸结合蛋白对乙型肝炎肝硬化食管静脉曲张的预测价值
- Author:
Caijun HAN
1
;
Zhengxie WU
;
Yuan HUANG
;
Xing JIN
;
Meihua PIAO
Author Information
1. 延边大学附属医院检验科，延吉 133000
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Esophageal varices;
Intestinal fatty acid-binding protein;
Biomarker
- From:
Chinese Journal of Laboratory Medicine
2025;48(11):1446-1451
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical predicting value of serum intestinal fatty acid-binding protein (I-FABP) in the development of esophageal varices (EV) in patients with chronic hepatitis B cirrhosis.Method:We used case-control study. A retrospective analysis was performed on the clinical data of 169 patients with hepatitis B cirrhosis who were admitted to the Affiliated Hospital of Yanbian University from September 2020 to October 2023. EV diagnosis and grades were based on gastroscopy. Enzyme-linked immunosorbent assay was used to measure the serum level of I-FABP on admission. Spearman correlation analysis was used to investigate the correlation among variables. Contributing factors of EV were evaluated using univariate and multivariate logistic regression analysis. Receiver operating characteristic (ROC) curves were used to evaluate the predictive performance of I-FABP for EV presence.Results:The gastroscopy showed 59 patients without EV. The median of I-FABP in the EV Group was significantly higher than that in the no-EV Group [2.01 (1.39, 2.89) μg/L vs 0.96 (0.77, 1.91) μg/L], and the difference was statistically significant ( Z=5.585, P<0.001). I-FABP showed significant positive correlations between model for end-stage liver disease sore and Von Willebrand Factor Antigen/thrombocyte Ratio ( r=0.523, 0.328, both P<0.001). Multiple logistic regression analysis identified I-FABP as the independent factor contributing to the presence of EV ( OR=1.73, P=0.045). The area under the curve of I-FABP predicting EV was 0.76. The cut-off was 1.46 μg/L. Conclusion:I-FABP is a potential marker for the formation of EV in patients with hepatitis B cirrhosis, and its increased concentration is related to reduced hepatic reserve and portal hypertension.
