The value of T1 mapping in the non-invasive assessment of the Oxford classification of IgA nephropathy
10.3760/cma.j.cn112138-20250523-00302
- VernacularTitle:T1 mapping定量参数对IgA肾病病理牛津分型的诊断价值
- Author:
Chaobo LI
1
;
Pu CHEN
;
Shaopeng ZHOU
;
Huanhuan KANG
;
Xuewei WEN
;
Sicheng YI
;
Xu BAI
;
Yong WANG
;
Li ZHANG
;
Haiyi WANG
Author Information
1. 解放军总医院第一医学中心放射诊断科，北京 100853
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, IgA;
Magnetic resonance imaging;
T1 mapping
- From:
Chinese Journal of Internal Medicine
2025;64(10):954-962
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic value of native T1 mapping in differentiating Oxford classification (MEST-C) scores in patients with IgA nephropathy.Methods:In this prospective study, patients who underwent both T1 mapping and renal biopsy at the First Medical Center of the Chinese PLA General Hospital between April 2023 and October 2024 were consecutively enrolled. Two radiologists, blinded to clinical and pathological information, measured renal T1 mapping parameters, including cortical T1 (cT1), medullary T1 (mT1), the corticomedullary difference (ΔT1), and the corticomedullary ratio (T1 ratio). Clinical and renal biopsy data based on the Oxford classification from patients with IgA nephropathy were collected. The Oxford classification includes five indicators: Mesangial hypercellularity (M), Endocapillary hypercellularity (E), Segmental glomerulosclerosis or adhesion (S), Tubular atrophy/interstitial fibrosis (T), and Cellular or fibrocellular crescents (C). Spearman correlation analysis was applied to evaluate the associations between MEST-C scores and T1 parameters. The diagnostic performance of T1 parameters for discriminating among scores of the Oxford classification was analyzed using the receiver operating characteristic (ROC) curve.Results:A total of 124 patients with IgA nephropathy were included in this study [66 males, 58 females; age 19-70 years, 39 (30, 51) years]. Except for the E indicator, M, S, T, and C were significantly correlated with renal T1 values ( ρ=0.177-0.414, all P<0.05). cT1 showed the best diagnostic efficacy for the S score, with an area under the curve (AUC) of 0.798, a sensitivity of 68.7%, and a specificity of 88.0%. The best T1 parameter for differentiating the T score was the T1 ratio, with an AUC of 0.687, a sensitivity of 57.9%, and a specificity of 79.1%. Conclusion:Native T1 mapping can be used for the non-invasive assessment of the S and T scores in the Oxford classification of patients with IgA nephropathy.
