The application analysis of antitoxin therapy in severe infant botulism
10.3760/cma.j.cn112140-20241017-00728
- VernacularTitle:重症婴儿肉毒中毒的抗毒素治疗应用分析
- Author:
Lijuan WANG
1
;
Quan WANG
;
Chaonan FAN
;
Kechun LI
;
Jun LIU
;
Zheng LI
;
Xinlei JIA
;
Jie WU
;
Yibing CHENG
;
Xinhui LUO
;
Fawudan ABUDU
;
Suyun QIAN
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院重症医学科，北京 100045
- Publication Type:Journal Article
- Keywords:
Botulism;
Infant;
Botulinum antitoxin;
Therapy;
Adverse reaction
- From:
Chinese Journal of Pediatrics
2025;63(3):254-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the application of antitoxin therapy in severe infant botulism.Methods:A retrospective analysis was conducted on 14 cases of severe infant botulism treated at 3 pediatric medical centers from July 2020 to August 2024. This study investigated antitoxin dosage, treatment duration, discontinuation criteria and adverse reactions.Results:A total of 14 cases (12 males and 2 females) were included, with an age of 5.0 (3.8, 7.0) months. Botulinum toxin typing revealed 10 cases of Type B, 2 cases of Type A and 2 untyped cases. The interval from symptom onset to antitoxin administration was 9.0 (6.0, 11.5) d. The initial dosage of type A antitoxin was 12 500 (10 000, 22 500) U, while type B was 5 000 (5 000, 5 000) U. The dosage was tapered in some cases after symptom improvement, the duration of treatment was 16.5 (9.8, 25.3) d. In total, 11 infants discontinued medications after improvement in muscle strength, while 3 infants discontinued treatment after obtaining negative results from fecal mouse bioassays. Adverse events were reported in 2 cases, both of which resulted in rash, and 1 case was complicated with anaphylactic shock. All the patients survived upon discharge with a follow-up period of 11 d to 3 years and 8 months. Totally 12 infants had fully recovered, while 2 infants were still recovering after discharge.Conclusion:Antitoxin therapy is a feasible and safe approach which showed favorable prognosis in severe infant botulism.
