Advances in brain metastasis mechanism of melanoma
10.3781/j.issn.1000-7431.2025.2406-0321
- VernacularTitle:黑素瘤脑转移机制的研究进展
- Author:
Zimeng WEI
1
;
Yu REN
;
Zhengyun ZOU
Author Information
1. 南京中医药大学中西医结合鼓楼临床医学院综合肿瘤中心,江苏 南京 210008
- Publication Type:Journal Article
- Keywords:
Melanoma;
Brain metastasis;
Metastasis mechanism
- From:
Tumor
2025;45(2):184-190
- CountryChina
- Language:Chinese
-
Abstract:
Among solid tumors,melanoma brain metastasis(MBM)has the highest incidence and is the leading cause of death in advanced melanoma patients.BRAF/MEK inhibitors and immune checkpoint inhibitors are currently effective treatments for brain metastases in melanoma patients.However,due to the existing blood-brain barrier and special intracranial microenviroment,the overall survival of patients has not been significantly improved,which has become a major difficulty in current treatment.Therefore,investigating the mechanisms of brain metastasis is crucial for refining the treatment strategies and improving the prognosis and survival outcomes in advanced melanoma patients.In this paper,the research progress of MBM mechanism in recent years is summarized,in order to provide new ideas for follow-up clinical work.
