The application and research progress in porphyrins and their derivatives in tumor therapy
10.3781/j.issn.1000-7431.2025.2404-0204
- VernacularTitle:卟啉及其衍生物在肿瘤治疗中的应用及研究进展
- Author:
Ziyu YANG
1
;
Jiekeng LAO
1
;
Huaqing LIN
1
Author Information
1. 广东药科大学广东省药物新剂型重点实验室,广东 广州 510006
- Publication Type:Journal Article
- Keywords:
Porphyrin;
Photodynamic therapy;
Sonodynamic therapy;
Radiotherapy;
Immunotherapy;
Tumor therapy
- From:
Tumor
2025;45(2):151-158
- CountryChina
- Language:Chinese
-
Abstract:
Porphyrin and its derivatives exhibit diverse biochemical properties because of their unique molecular structures,and have been widely used and recognized in the field of tumor therapy.The applications of chemical modifications and nanotechnology have not only significantly enhanced the biological activity of porphyrins and their derivatives but also substantially improved the drug delivery efficiency.In addition,the applications of porphyrins and their derivatives in multiple therapeutic methods,including photodynamic therapy(PDT),sonodynamic therapy(SDT),radiotherapy and immunotherapy,have opened the door for the implementation of tumor multimodal treatment strategies.This cross-disciplinary integration facilitates the overcoming of limitations inherent to single-modality treatments,thereby synergistically enhancing overall therapeutic efficacy aganist tumors.This review systematically summarizes recent advances in the applications of porphyrins and their derivatives within the aforementioned therapeutic treatments,and the challenges and future development potential of porphyrins and their derivatives in tumor therapy are respectively discussed and prospected.
