Meta-analysis of the efficacy and safety of traditional Chinese medicine for soothing the liver in the treatment of dual heart disease
10.3969/j.issn.1008-9691.2025.03.009
- VernacularTitle:疏肝中药治疗双心病有效性与安全性的Meta分析
- Author:
Haiyun ZHU
1
;
Ting LI
;
Yingdong WU
Author Information
1. 天津市中医药研究院附属医院心血管内科,天津 300120
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medicine for soothing the liver;
Cardiovascular diseases;
Psychological disorder;
Meta-analysis
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2025;32(3):306-310
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a Meta-analysis on the efficacy and safety of traditional Chinese medicine for soothing the liver for soothing the liver in the treatment of double heart disease.Methods China National Knowledge Infrastructure(CNKI),VIP Database,Wanfang Database,China Biology Medicine disc(CBMdisc),Chinese Clinical Trial Registry,PubMed Database,Cochrane Library were searched.Randomized controlled trials on the treatment of cardiovascular diseases combined with mental disorders(anxiety and depression,etc.)with traditional Chinese medicine for soothing the liver were collected from March 28,2025.The control group received conventional treatment,while the observation group was treated with additional soothing the liver traditional Chinese medicine in addition to the conventional therapy.The outcome indicators included the overall clinical efficacy,the score of the self-rating depression scale(SDS),the score of the self-rating anxiety scale(SAS),and the incidence of adverse reactions.A Meta-analysis was conducted using Stata 15.0 statistical software,and a funnel plot was drawn to evaluate publication bias in the literature.Results A total of 14 literatures were included,all of which were in Chinese.The results of the Meta-analysis showed that compared with the control group,the observation group treated with addition traditional Chinese medicine for soothing the liver could effectively improve the clinical efficacy[odds ratio(OR)=2.14,95%confidence interval(95%CI)was1.71-2.68,P=0.00],and improve the depressive and anxious state of patients[depression:Standardized mean difference(SMD)=-2.00,95%CI was-2.92 to-1.07,P=0.00;anxiety:SMD=-1.88,95%CI was-2.42 to-0.99,P=0.00].The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(16.1%vs.34.0%,χ2=29.347,P<0.05).Conclusion The total effective rate and safety of patients treated with traditional Chinese medicine for soothing the liver on the basis of conventional treatment are higher.
