One case of renal amyloidosis combined with minimal change disease
10.3760/cma.j.cn441217-20240822-00827
- VernacularTitle:肾淀粉样变性合并微小病变肾病1例
- Author:
Sushan LUO
1
;
Tong WU
;
Naya HUANG
;
Wenfang CHEN
;
Fengxian HUANG
;
Wei CHEN
;
Qinghua LIU
;
Jianwen YU
Author Information
1. 中山大学附属第一医院肾内科，国家卫生健康委员会肾脏病临床研究重点实验室（中山大学），广东省肾脏病重点实验室，广州 510080
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Amyloidosis;
Nephrosis, lipoid;
Biopsy;
Primary systemic immunoglobulin light chain amyloidosis
- From:
Chinese Journal of Nephrology
2025;41(7):540-543
- CountryChina
- Language:Chinese
-
Abstract:
This paper presents a rare case of renal amyloidosis complicated with primary minimal change disease. The patient initially presented with edema and proteinuria, accompanied by IgG-λ monoclonal immunoglobulinemia, leading to a diagnosis of primary systemic immunoglobulin light chain amyloidosis with renal involvement. Following treatment, the patient achieved both hematologic and renal remission. However, a renal relapse occurred two years later, presenting as nephrotic syndrome without hematologic disease recurrence. A repeat renal biopsy revealed no obvious change in amyloid deposition, but demonstrated markedly enlarged effacement of podocyte foot processes. Based on these findings, a secondary diagnosis of primary minimal change disease was established. The patient exhibited a rapid response to immunosuppressive therapy, achieving sustained long-term remission. This case underscores the importance of remaining vigilant to etiological changes in the treatment of renal diseases and highlights the role of repeated renal biopsy in refining the diagnosis and guiding treatment.
