Application of peritoneal dialysis in the treatment of critically ill neonates with acute kidney injury
10.3760/cma.j.cn441217-20250421-00449
- VernacularTitle:腹膜透析在危重症新生儿急性肾损伤抢救中的应用
- Author:
Na CHEN
1
;
Lina FU
1
;
Yaqi MA
1
;
Dongxing XIAO
1
;
Li WANG
1
;
Shuhua SONG
1
;
Xiaoqin MA
1
;
Yan WANG
1
;
Na TIAN
1
Author Information
1. 宁夏医科大学总医院肾脏内科 宁夏肾脏病临床研究中心，银川 750004
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Infant, newborn;
Acute kidney injury;
Critical care nursing
- From:
Chinese Journal of Nephrology
2025;41(11):849-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of peritoneal dialysis (PD) in the treatment of acute kidney injury (AKI) in critically ill neonates.Methods:It was a retrospective study. The baseline characteristic data, PD protocols, PD catheter placement methods and clinical outcomes of AKI neonates who underwent PD in the General Hospital of Ningxia Medical University between July 2015 and December 2024 were collected and analyzed.Results:(1) Among the 8 neonates with AKI, gestational age was (30.38±6.02) weeks, and birth weight was 1 397.5 (839.0, 2 312.5) g, with 6 premature infants. The time from birth to AKI onset was 144 (48, 294) hours. The leading cause of AKI was sepsis (6/8). The treatment time of PD was (93.12±37.20) hours. (2) Renal function recovery: After PD treatment, urine output was significantly increased ( Z=-3.29, P<0.001), and serum creatinine was significantly decreased ( t=2.66, P=0.032). (3) Hyperkalemia: Six out of 8 patients presented with hyperkalemia, which significantly decreased after PD treatment ( t=3.37, P=0.008). (4) Acid-base balance:Five out of 8 neonates had metabolic acidosis, and 3 of 5 neonates achieved basically complete correction (including lactic acidosis). There was no statistically significant difference in acid-base balance indicators before and after PD treatment (all P>0.05). (5) PD-related complications: Two out of 8 patients experienced peritoneal dialysate leakage, and no other PD-related complications occurred. (6) Outcomes: The hospital stay was 27.0 (8.0, 57.5) days. Four out of 8 neonates survived, while the other 4 neonates died after withdrawal of treatment. The primary cause was multiple organ failure. Conclusions:PD is a safe and effective treatment for neonatal AKI, facilitating early renal recovery and correction of electrolyte and acid-base imbalances.
