Membranous nephropathy with monoclonal IgG1-κ deposits in an adolescent
10.3760/cma.j.cn441217-20241025-01039
- VernacularTitle:伴单克隆IgG1-κ沉积的青少年膜性肾病1例
- Author:
Xiang FANG
1
;
Pei ZHANG
;
Shaoshan LIANG
;
Chenxi MA
;
Zhengkun XIA
;
Chunlin GAO
Author Information
1. 南京大学医学院附属金陵医院（东部战区总医院）儿科，南京 210002
- Publication Type:Journal Article
- Keywords:
Immunoglobulins;
Glomerulonephritis, membranous;
Adolescent;
Proliferative glomerulonephritis;
Monoclonal immunoglobulin
- From:
Chinese Journal of Nephrology
2025;41(10):772-775
- CountryChina
- Language:Chinese
-
Abstract:
This article reports a case of membranous nephropathy in an adolescent accompanied by monoclonal IgG1-κ deposition. The 16-year-old female patient was hospitalized for experiencing proteinuria and hematuria for more than 20 days. The patient had a history of mycoplasma infection and acute kidney injury, and renal pathology revealed glomerular membrane lesions accompanied by crescent formation. Electron microscopy showed electron dense deposits in the subepithelial and mesangial regions, and immunofluorescence demonstrated monotypic IgG1-κ deposits in the glomerulus. Bone marrow examination did not find any abnormal plasma cells, nor were there significant abnormalities in serum or urine free light chain κ/λ ratio. The diagnosis was proliferative glomerulonephritis characterized by membranous lesions with monoclonal IgG1-κ deposits. This disease is rare in children and adolescents, and currently there is limited understanding of its mechanism, with limited clinical treatment experience. This article aims to provide clinical insights through case analysis and literature review.
