Clinicopathological features of IgA nephropathy with monotypic IgA deposition and its relationship with proliferative glomerulonephritis with monoclonal IgA deposit
10.3760/cma.j.cn441217-20240822-00825
- VernacularTitle:单型IgA沉积IgA肾病的临床病理特点及其与单克隆IgA沉积伴增生性肾小球肾炎的关系
- Author:
Xiaoying LI
1
;
Guangliang XIE
;
Ji ZHANG
;
Jiansheng CHEN
;
Xiaokai DING
Author Information
1. 浙江瑞安市中医院肾内科，瑞安 325200
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, IgA;
Immunoglobulin A;
Proliferative nephritis;
Monotypic IgA;
Monoclonal IgA;
Renal pathology
- From:
Chinese Journal of Nephrology
2025;41(9):713-717
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy (IgAN) is a glomerulonephritis characterized by diffuse deposition of immune complexes mainly composed of IgA in the mesangial area of the glomerulus. However, some patients show monotypic IgA deposits in the immunofluorescence examination, and its clinicopathological significance is not yet clear. The renal pathological changes of IgAN with monotypic IgA deposition are similar to those of proliferative glomerulonephritis with monoclonal IgA deposit (IgA-PGNMID), which has a risk of progressing to hematological malignancies and a worse clinical prognosis. It is necessary to differentiate them based on clinical pathological manifestations and hematological examinations. Based on previous literature reports and the research results of our research group, this review summarizes and analyzes the mechanism, clinical and pathological characteristics, and prognosis of IgAN with monotypic IgA deposition, and the relationship between IgAN with monotypic IgA deposition and IgA-PGNMID, to improve clinical doctors' understanding of IgAN with monotypic IgA deposition, reduce missed diagnosis and misdiagnosis, and improve patients' prognosis.
