Hematopoietic stem cell and kidney transplantation from the same donor in a patient with acute myeloid leukemia and literature review
10.3760/cma.j.cn441217-20240929-00956
- VernacularTitle:急性髓系白血病患者接受同一供体造血干细胞移植与肾移植1例及文献复习
- Author:
Yan YIN
1
;
Zilin QUAN
;
Li SONG
;
Zhonglin FENG
;
Dongmei CUI
;
Liyan ZHAO
;
Yuhang HU
;
Qinghua ZHOU
;
Xiaoli KANG
;
Junjie LIAO
;
Qizhen LIANG
;
Suijin WU
;
Hongmei WU
;
Shuangxin LIU
Author Information
1. 南方医科大学附属广东省人民医院（广东省医学科学院）肾内科，广州 510080
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Graft vs host disease;
Kidney transplantation;
Renal allotransplantation
- From:
Chinese Journal of Nephrology
2025;41(9):691-695
- CountryChina
- Language:Chinese
-
Abstract:
The paper reports a 32-year-old female acute myeloid leukemia patient who developed graft-versus-host disease after paternal hematopoietic stem cell transplantation, which subsequently led to renal thrombotic microangiopathy. She subsequently required a kidney transplant from the same donor 5 years later due to renal failure. Considering that both the bone marrow and kidney were from the same donor and the recovery of renal function was favorable, immunosuppressive therapy was discontinued after a short course of anti-rejection treatment, with maintained stable kidney function. This case suggests that under the condition of high chimerism, allogeneic hematopoietic stem cell transplantation and kidney transplantation from the same donor can achieve immune tolerance, potentially improving solid organ transplantation success rate. The findings provide a novel therapeutic approach for solid organ transplantation following allogeneic hematopoietic stem cell transplantation.
