Research progress on the role of Akkermansia muciniphila in kidney diseases
10.3760/cma.j.cn441217-20240523-00533
- VernacularTitle:阿克曼菌在肾脏疾病中作用的研究进展
- Author:
Fei CHEN
1
;
Jie TANG
;
Qianqian WEI
;
Yanan BAN
;
Hailin ZHANG
Author Information
1. 徐州医科大学附属连云港医院血液净化中心，连云港 222061
- Publication Type:Journal Article
- Keywords:
Akkermansia;
Gastrointestinal microbiome;
Kidney diseases
- From:
Chinese Journal of Nephrology
2025;41(6):449-454
- CountryChina
- Language:Chinese
-
Abstract:
Akkermansia muciniphila, a probiotic is discovered years earlier, colonizes the human intestinal mucosa. In recent years, researchers have found the correlation between Akkermansia muciniphila and progression of kidney diseases based on the theory of the gut-kidney axis. The abundance of Akkermansia muciniphila in the gut changes during the onset, regression and treatment of renal diseases such as congenital nephrology, chronic kidney disease, complications after renal transplantation. The research on the correlation between Akkermansia muciniphila and renal diseases is still in the initial stage. The review introduces the research progress on the role of Akkermansia muciniphila in renal diseases from three aspects: the biological characteristics of Akkermansia muciniphila, the abundance change in the progression of renal diseases, and their biological effects to provide references for the following research on the mechanisms of Akkermansia muciniphila in renal diseases and the application of clinical renal disease treatment.
