Relationship of cathepsin K and secreted frizzled-related protein 2 with postoperative ventricular remodeling in very old adults with AMI
10.3969/j.issn.1009-0126.2025.10.009
- VernacularTitle:组织蛋白酶K和分泌型卷曲相关蛋白2与高龄急性心肌梗死患者术后心室重构的关系
- Author:
Qiong HU
1
;
Li YANG
1
;
Qian YANG
1
;
Ying FENG
1
Author Information
1. 430022 武汉市第一医院心血管内科
- Publication Type:Journal Article
- Keywords:
cathepsin K;
myocardial infarction;
ventricular remodeling
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(10):1326-1329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of cathepsin K(CTK)and secreted frizzled-related protein 2(sFRP2)in ventricular remodeling in very old patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI),and analyze the correlation.Methods A total of 192 very old AMI patients undergoing PCI in our department from January 2020 to December 2023 were recruited,and based on clinical outcomes at 6 months after surgery,they were assigned into a ventricular remodeling group(74 cases)and a non-ventricular remodeling group(118 cases).The clinical data and postoperative biochemical indicators were collected in the two groups.Multivariate logistic regression analysis was performed to assess the correlation between CTK and sFRP2 levels and ventricular remodeling.ROC curves were plotted to analyze the predictive value of CTK and sFRP2 in ventricular remodeling.Results The ventricular remodeling group had significantly longer length of hospital stay,larger left ventricular end-diastolic diameter,and higher levels of CTK,sFRP2,C-reactive protein(CRP)and IL-6,but lower left ventricular ejection fraction than the non-ventricular remodeling group(P＜0.05,P＜0.01).Multivariate logistic regression analysis suggested that CTK and sFRP2 were independent risk factors for postoperative ventricular remodeling in very old AMI patients(P＜0.01).ROC curve analysis manifested that the area under curve value of CTK,sFRP2,CRP and IL-6 combined together in predicting ventricular remodeling in very old AMI patients after PCI was 0.892,with a sensitivity of 79.73％and a specificity of 88.14％(P＜0.01).Conclusion CTK and sFRP2 are significantly increased in ventricular remodeling in very old AMI patients after PCI,and are closely related to the occurrence of ventricular remodeling.They can be used as potential biomark-ers in the prediction of ventricular remodeling and provide important reference for clinical diagno-sis and treatment.
