Correlation between gut microbiota metabolite trimethylamine-N-oxide and total imaging burden in diabetic patients with CSVD
10.3969/j.issn.1009-0126.2025.10.005
- VernacularTitle:肠道菌群代谢产物氧化三甲胺与糖尿病脑小血管病影像学总负荷的相关性
- Author:
Pan WANG
1
;
Jingyu DENG
;
Yunuo CHEN
;
Yachen SHI
;
Min XU
;
Xiangming FANG
;
Feng WANG
;
Guangjun XI
Author Information
1. 214023 南京医科大学附属无锡人民医院神经内科
- Publication Type:Journal Article
- Keywords:
cerebral small vessel disease;
diabetes;
total imaging burden;
trimethylamine N-oxide
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(10):1309-1312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between gut microbiota metabolite,trimethy-lamine-N-oxide(TMAO),and total imaging burden in diabetic patients with cerebral small vessel disease(CSVD).Methods A prospective study was conducted on 112 elderly diabetic patients with CSVD admitted in our hospital from June 2022 to May 2024.According to the total imaging burden score,they were divided into a high burden group(burden score≥2,57 cases)and a low burden group(burden score＜2,55 cases).High-performance liquid chromatography with online electrospray ionization tandem mass spectrometry was applied to detect the plasma level of TMAO.Then based on the tertile of plasma TMAO level,the patients were also assigned into low(＜2.44 μmol/L,38 cases),median(2.44 μmol/L≤TMAO＜5.18 μmol/L,37 cases)and high TMAO(≥5.18 μmol/L,37 cases)groups.ROC curve analysis was used to assess the predictive value of plasma TMAO level for high imaging burden in diabetic patients with CSVD.Binary logistic regression analysis was employed to analyze the correlation between plasma TMAO level and high imaging burden.Results The high burden group exhibited significantly higher plasma TMAO level than the low burden group(P=0.002).The AUC value of plasma TMAO level in predicting high imaging burden was 0.669(95％CI:0.569-0.769,P=0.002).The percentage of high imaging burden was 34.2％,54.1％and 64.9％,respectively among the low,median and high TMAO groups,with significant differences among them(Chi-square=7.270,P=0.026).Binary logistic regression analysis indicated the correlation between TMAO and high imaging burden(OR=1.178,95％CI:1.019-1.364,P=0.027).Conclusion In elderly diabetic patients with CSVD,plasma TMAO level is closely associated with high imaging burden,with higher TMAO level,higher risk for high imaging burden.
