Analysis of the infection status of severe fever with thrombocytopenia syndrome virus in Beijing in 2024
10.3760/cma.j.cn112866-20250303-00046
- VernacularTitle:北京市2024年发热伴血小板减少综合征病毒感染状况分析
- Author:
Yulan SUN
1
;
Xiangfeng DOU
1
;
Weijia ZHANG
1
;
Yanwei CHEN
1
;
Fu LI
1
;
Haoyuan JIN
1
;
Zhenyong REN
1
;
Dan LI
1
;
Daitao ZHANG
1
Author Information
1. 北京市疾病预防控制中心
- Publication Type:Journal Article
- Keywords:
Severe fever with thrombocytopenia syndrome virus;
Tick;
Parthenogenesis;
Genotype;
Healthy populations
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(2):136-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the epidemiological characteristics of severe fever with thrombocytopenia syndrome (SFTS) in Beijing in 2024, to investigate the infection status of reservoir hosts, vector organisms, and baseline human populations, and provide a scientific basis for formulating prevention and control strategies.Methods:Epidemiological surveys were conducted on all confirmed cases. Serum samples from healthy populations and reservoir hosts were collected for SFTSV antibody detection. Questing ticks were monitored using the flagging method. Real-time fluorescent quantitative PCR was employed to detect SFTSV in cases, reservoir hosts, and ticks. Positive samples underwent whole-genome sequencing and genetic evolution analysis.Results:In 2024, Beijing reported 15 locally infected cases with 4 deaths. The age of onset ranged from 50 to 80 years (median: 66 years). Cases showed a certain degree of geographical clustering, with June being the peak month of onset. The affected population was predominantly farmers, with a male-to-female ratio of 3∶2. Animal contact history emerged as a significant risk factor alongside tick bites. Parthenogenetic tick populations were identified in Pinggu district, while SFTSV-carrying ticks were detected in endemic areas (Mentougou, Shijingshan, and Fengtai Districts). Viral presence was also confirmed in ticks or dogs from non-endemic areas. Sequencing and phylogenetic analysis revealed stable clustering of strains into two distinct genotypes (A and B). Antibody-positive individuals were identified in healthy populations from non-endemic areas.Conclusions:The incidence of SFTS in Beijing is increasing, with natural viral circulation already established in non-endemic regions. Enhanced surveillance and adjusted prevention strategies are urgently needed.
