Effect of Preoperative Oral Electrolyte Solution on Stress Response and Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery Patients:a Randomized Controlled Study
10.3969/j.issn.1009-6604.2025.09.002
- VernacularTitle:术前口服电解质溶液对妇科腹腔镜手术患者应激反应和恶心呕吐的影响:随机对照研究
- Author:
Huichun CAI
1
;
Jiangbin CHU
;
Meihua WU
;
Jingjia YAN
Author Information
1. 晋江市医院 上海市第六人民医院福建医院妇科,泉州 362200
- Publication Type:Journal Article
- Keywords:
Ectrolyte solution;
Gynaecology;
Laparoscopic surgery;
Stress response;
Enhanced Recovery After Surgery;
Postoperative nausea and vomiting
- From:
Chinese Journal of Minimally Invasive Surgery
2025;25(9):518-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of preoperative oral electrolyte solution on intraoperative stress response and postoperative nausea and vomiting(PONV)in patients undergoing gynecological laparoscopic surgery.Methods From January to April 2025,200 cases of elective gynecological laparoscopic surgery due to benign diseases were selected and randomly divided into observation group and control group by the envelope method,with 100 cases in each group.The observation group orally took 5 ml/kg electrolyte solution(with a maximum dose of 300 ml)at 2 h before surgery,while the control group was fasted and prohibited from drinking at 2 h before the operation according to the traditional protocol.The mean arterial pressure(MAP),heart rate(HR),end-tidal CO2 partial pressure(PETCO2),Cerebral State Index(CSI),and pneumoperitoneum pressure were recorded at 6 time points:entering the room(T1),entering the laparoscope(T2),30 min after the start of the operation(T3),60 min after the start of the operation(T4),the end of the operation(T5),and 30 min after the operation(T6).The blood samples were taken at T3 and T6 to detect catecholamines(adrenaline,norepinephrine,dopamine),cortisol,and blood glucose levels.The recovery time of bowel sounds,anal exhaust time,and incidence of PONV within 2,6,and 12 h after surgery were recorded.Results There were no statistically significant differences in MAP,HR,PETCO2,CSI,and pneumoperitoneum pressure between the two groups(P＞0.05).The average levels of norepinephrine at T3 and T6 and blood glucose at T3 in the observation group were lower than those in the control group(P＜0.05).The incidence of PONV at 2,6,and 12 h after surgery,recovery time of bowel sounds,and anal exhaust time were all better in the observation group than those in the control group(P＜0.05).Conclusion Preoperative oral electrolyte solution can effectively alleviate the intraoperative stress response of gynecological laparoscopic surgery patients,reduce the incidence of PONV,promote the recovery of gastrointestinal function,and conform to the concept of Enhanced Recovery After Surgery(ERAS).
