A case of membranous nephropathy following allogeneic hematopoietic stem cell transplantation in a child with adrenoleukodystrophy
10.3760/cma.j.cn441217-20240523-00531
- VernacularTitle:以肾上腺脑白质营养不良起病的儿童异基因造血干细胞移植后继发膜性肾病1例
- Author:
Xiang FANG
1
;
Chunlin GAO
;
Pei ZHANG
;
Feng XU
;
Zilu TANG
;
Zhengkun XIA
Author Information
1. 南京大学医学院附属金陵医院儿科，南京 210002
- Publication Type:Journal Article
- Keywords:
Haemopoietic stem cell transplantation;
Graft vs host disease;
Nephrotic syndrome;
Child
- From:
Chinese Journal of Nephrology
2025;41(3):209-212
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic haemopoietic stem cell transplantation (allo-HSCT)-related nephrotic syndrome is a rare complication, recognized as a clinical manifestation of chronic graft versus host disease (GVHD). T cell dysfunction is thought to play a significant role in the pathogenesis of allo-HSCT-related nephrotic syndrome, but the precise mechanism remains unclear. This paper reported a case of X-linked adrenoleukodystrophy (X-ALD) who had good control of the disease after allo-HSCT, but developed proteinuria and progressed to nephrotic syndrome after immunosuppressive therapy was tapered. Kidney biopsy revealed secondary membranous nephropathy, which responded well to treatment with glucocorticoids and tacrolimus. Limited literature exist on allo-HSCT-related nephrotic syndrome in children. This study provides a comprehensive summary of its mechanism, clinical features, pathology, diagnosis,and treatment, offering valuable insights for diagnosing and managing allo-HSCT-related nephrotic syndrome in pediatric patients.
