Analysis of the prevalence and clinical characteristics of pertussis in children with different cough durations
10.3760/cma.j.cn112150-20250628-00601
- VernacularTitle:不同咳嗽时长患儿的百日咳患病情况及临床特征分析
- Author:
Wenting LI
1
;
Lei LI
;
Fuling WU
;
Yongli JIAO
;
Xiaowei ZHANG
;
Jing LI
;
Ruizhen ZHANG
;
Lei WANG
;
Xiang MA
Author Information
1. 山东大学附属儿童医院呼吸内科，济南 250022
- Publication Type:Journal Article
- Keywords:
Pertussis;
Acute cough;
Protracted acute cough;
Chronic cough;
Children;
Cross-sectional studies
- From:
Chinese Journal of Preventive Medicine
2025;59(11):1855-1860
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence and clinical characteristics of pertussis in children with different cough durations.Methods:From January 2021 to October 2022, information on children aged 0-18 years who visited eight hospitals in Shandong Province due to cough was enrolled. Pertussis serological antibody testing and/or nucleic acid testing were performed. The prevalence and clinical characteristics of pertussis were compared among the acute cough group, protracted cough group, and chronic cough group using the χ2 test or Fisher′s exact test. Results:A total of 1 565 children with cough were included in the study, of which 348 (22.24%) were laboratory-confirmed pertussis. There was a significant difference in the laboratory-confirmed rate of pertussis among different cough groups ( χ2=83.424, P<0.001). The confirmation rate of pertussis in the protracted cough group (42.21%) was significantly higher than that in the acute cough group (16.49%, P<0.05) and chronic cough group (19.50%, P<0.05). In each cough group, the age of children was significantly associated with the confirmed rate of pertussis, and the confirmed rate was relatively high in children aged 3 months to <2 years. Pertussis vaccination was significantly associated with the confirmed rate in all groups, and the confirmed rate was higher in unvaccinated children. Among laboratory-confirmed pertussis cases, the incidence of typical symptoms such as paroxysmal cough, whoop, and post-tussive emesis or sleep disturbance was significantly higher than that in the non-confirmed cases. In the protracted and chronic cough groups, the proportion of non-confirmed cases complicated with asthma/cough variant asthma (CVA) was significantly higher than that in pertussis-confirmed cases. Conclusion:There are differences in the confirmation rate of pertussis among children with different cough durations. The confirmation rate is significantly associated with age, vaccination status, and clinical symptoms. Enhancing clinical vigilance against pertussis, conducting early diagnosis, and getting timely and standardized vaccination are crucial for effectively controlling pertussis and preventing outbreaks.
