Methimazole-induced anti-neutrophil cytoplasmic antibody associated vasculitis: a case report and literature review
10.3760/cma.j.cn441217-20240201-00202
- VernacularTitle:甲巯咪唑致抗中性粒细胞胞质抗体相关性血管炎1例并文献复习
- Author:
Haiwei NI
1
;
Sailaiajimu GUZAILINUER·
1
;
Jingjing ZHANG
1
;
Zhen LIU
1
;
Chen LU
1
Author Information
1. 新疆医科大学第一附属医院肾脏疾病中心 国家肾脏疾病临床医学研究中心新疆分中心 新疆维吾尔自治区肾脏病研究所，乌鲁木齐 830011
- Publication Type:Journal Article
- Keywords:
Methimazole;
Anti-neutrophil cytoplasmic antibody-associated vasculitis;
Multiple organ failure;
Anti-glomerular basement membrane disease;
Rapidly progre
- From:
Chinese Journal of Nephrology
2025;41(2):128-133
- CountryChina
- Language:Chinese
-
Abstract:
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) induced by anti-thyroid drugs has been reported occasionally, but methimazole-induced AAV is not as frequently reported. This case report described a 54-year-old male who developed AAV and multiple organ failure after more than 20 days of methimazole treatment. After timely discontinuation of the disease-causing drug methimazole, the patient received methylprednisolone shock, cyclophosphamide immunosuppression, renal replacement therapy, and other supportive treatments, and the disease was alleviated without recurrence.
