A case report of neonatal hypothyroidism induced by high maternal thyroid stimulating hormone receptor antibody level during pregnancy
10.3760/cma.j.cn311282-20250103-00005
- VernacularTitle:一例妊娠期母体高滴度促甲状腺激素受体抗体致新生儿甲状腺功能减退的病例报告
- Author:
Tao BAI
1
;
Weijie SUN
;
Peiheng ZHANG
;
Yang ZHANG
;
Huixia YANG
;
Ying GAO
Author Information
1. 北京大学第一医院内分泌科，北京 100034
- Publication Type:Journal Article
- Keywords:
Thyroid stimulating hormone receptor antibody;
Fetal hypothyroidism;
Neonatal hypothyroidism
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(6):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Maternal high titers of thyroid stimulating hormone receptor antibody(TRAb) during pregnancy can cause fetal and neonatal thyroid dysfunction, among which hypothyroidism is relatively rare. In this case, the woman was diagnosed with Hashimoto′s hypothyroidism prior to pregnancy and was treated with levothyroxine(LT 4) to maintain normal thyroid function throughout gestation. Despite normal maternal thyroid function, TRAb levels remained persistently elevated during pregnancy. The fetus showed a normal fetal thyroid circumference and heart rate, but no secondary ossification center was observed at 37 + 6 weeks of gestation. On the 9th day after birth, the neonate was diagnosed with congenital hypothyroidism and started on LT 4 replacement therapy. By 7 months of age, thyroid function had normalized, and LT 4 was discontinued. This case highlights the importance of close monitoring of fetal growth and neonatal thyroid function in pregnant women with high TRAb titers, to ensure timely detection and management of fetal and neonatal thyroid dysfunction.
