Clinical management of lipoatrophic diabetes
- VernacularTitle:脂肪萎缩性糖尿病的临诊应对
- Author:
Tianyuan JIANG
1
;
Qin ZHEN
1
;
Yanyun HU
1
;
Muyu YU
1
;
Na LI
1
;
Yufan WANG
1
;
Fang LIU
1
;
Yongde PENG
1
Author Information
- Publication Type:Journal Article
- Keywords: Lipoatrophy; Diabetes mellitus; Lipodystrophy syndrome; Insulin resistance
- From: Chinese Journal of Endocrinology and Metabolism 2025;41(5):417-423
- CountryChina
- Language:Chinese
- Abstract: Lipoatrophic diabetes(LD) is a rare and distinct form of diabetes characterized by notable clinical heterogeneity. It is often considered one of the manifestations of lipodystrophy syndrome(LDS). In clinical practice, LD is frequently misdiagnosed as type 2 diabetes; however, its management protocols and prognostic outcomes differ significantly from those of other diabetes subtypes. Therefore, timely and accurate diagnosis is of great clinical importance. This paper presents two detailed case reports of female patients with LD. Through an in-depth analysis of their clinical features, it also provides an comprehensive review of the key clinical manifestations of LDS, potential pathogenic mechanisms, and current approaches to genetic diagnosis. The aim is to enhance clinicans′ awareness of LDS and improve corresponding diagnostic and therapeutic strategies.
