Association of metabolic syndrome status change and risk of carotid plaque
10.3760/cma.j.cn311282-20240914-00417
- VernacularTitle:代谢状态转变与颈动脉斑块发病风险关联的队列研究
- Author:
Shuang LIU
1
;
Xinlei MIAO
;
Ziping SONG
;
Xiaoling XIE
;
Manling HU
;
Yuting SUN
;
Fei XU
;
Song LENG
Author Information
1. 大连医科大学附属第二医院健康管理中心，大连 116023
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Carotid plaque;
Carotid intima-media thickness;
Cardiovascular disease
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(3):204-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of changes in metabolic syndrome status and persistence on carotid plaque risk.Methods:This retrospective cohort study analyzed individuals who underwent routine health check-ups at the health management center of the Second Affiliated Hospital of Dalian Medical University from 2014 to 2023. Participants with at least three carotid ultrasound records meeting the inclusion criteria were classified into 4 groups based on changes in metabolic status: persistently metabolic health, transitioning from metabolic health to unhealth, transitioning from metabolic unhealth to health, and persistently metabolic unhealth. The cumulative incidence of carotid plaque in these groups was compared. A Cox proportional risk model was used to evaluate the relationship between changes in metabolic syndrome status, the number of metabolic syndrome components, and the risk of carotid plaque development. Restricted cubic spline analysis was applied to explore the association between changes in individual metabolic syndrome components and carotid plaque risk.Results:Compared to the persistently metabolic health group, the persistent unhealth group had the highest risk of developing carotid plaque( HR=1.35, 95% CI 1.05-1.74, P=0.021), followed by those who transitioned from metabolic health to unhealth and those who improved from metabolic unhealth to health. Furthermore, the risk of carotid plaque increased progressively with the number of metabolic syndrome components. Restricted cubic spline analysis revealed a nonlinear relationship between fasting blood glucose change and carotid plaque risk, while systolic blood pressure, diastolic blood pressure, waist circumference, triglycerides, and high-density lipoprotein-cholesterol showed a linear dose-response relationship with carotid plaque. Conclusions:The change of metabolic syndrome is associated with the risk of developing carotid plaque, and maintaining metabolic health, recovering from metabolic syndrome, or minimizing the number of metabolic syndrome components may be effective strategies to prevent carotid plaque formation.
