Effects of glucokinase activators on pancreatic β-cell function in patients with type 2 diabetes mellitus
10.3760/cma.j.cn311282-20241106-00526
- VernacularTitle:葡萄糖激酶激活剂对2型糖尿病患者胰岛β细胞功能的影响
- Author:
Shuqin PENG
1
;
Mingyang ZHAO
1
;
Min WANG
1
Author Information
1. 中南大学湘雅医院内分泌科，长沙 410008
- Publication Type:Journal Article
- Keywords:
Glucokinase;
Glucokinase activator;
Pancreatic β-cell;
Diabetes mellitus, type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(8):699-703
- CountryChina
- Language:Chinese
-
Abstract:
Glucokinase serves as the glucose sensor in pancreatic β-cells. Glucokinase activators can effectively increase the mass and improve the function of pancreatic β-cells in patients with type 2 diabetes, thereby enhancing insulin synthesis and secretion while reducing β-cell apoptosis. This article reviews recent advances in research on the effects of glucokinase activators on pancreatic β-cells and provides an in-depth analysis of how these agents optimize β-cell function, discussing their potential to offer more effective therapeutic strategies for patients with type 2 diabetes.
