Long-term weight management in obese patients: Strategies to address weight regain
10.3760/cma.j.cn311282-20250407-00178
- VernacularTitle:肥胖患者的长期体重管理：如何应对体重反弹？
- Author:
Jiajing YIN
1
;
Shen QU
1
Author Information
1. 同济大学附属第十人民医院肥胖症诊治中心，上海 200072
- Publication Type:Journal Article
- Keywords:
Obesity;
Weight;
Management;
Weight regain
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(7):533-539
- CountryChina
- Language:Chinese
-
Abstract:
The global burden of obesity continues to rise, and the long-term management of body weight remains a significant challenge. Virtually all current weight loss interventions are associated with varying degrees of weight regain following initial weight reduction, which compromises the long-term benefits for patients with obesity. Multiple complex physiological mechanisms contribute to this phenomenon, including the regulation of body weight " set points" , alterations in energy expenditure and metabolic adaptation, central nervous system control, and the modulatory effects of obesity-associated immune cells. Targeted interventions addressing these regulatory pathways may help mitigate weight regain. In recent years, several novel therapeutic strategies have emerged, such as nutrient-stimulated hormone-based agents, compounds that enhance the efficacy of glucagon-like peptide-1 receptor agonists, leptin-sensitizing agents, and medications that improve body composition. These innovations offer promising opportunities to sustain weight loss and prevent subsequent regain. This review aims to summarize the underlying mechanisms of weight regain and discuss emerging strategies to address this challenge, providing new perspectives for optimizing the long-term clinical management of obesity.
