Recent advances in osteoporosis in children and adolescents
- VernacularTitle:儿童及青少年骨质疏松症研究进展
- Author:
Kangkang NI
1
;
Dan DONG
1
;
Guoqing LI
1
;
Lianguo WU
1
;
Bocheng LIANG
1
;
Shaoning SHEN
1
;
Jie LI
1
;
Yawei XU
1
;
Chao XU
1
Author Information
- Publication Type:Journal Article
- Keywords: Primary osteoporosis; Secondary osteoporosis; Genetic testing; Osteogenesis imperfecta
- From: Chinese Journal of Endocrinology and Metabolism 2025;41(5):430-434
- CountryChina
- Language:Chinese
- Abstract: Osteoporosis is a systemic metabolic disease characterized by decreased bone mass, leading to an increased risk of fractures. Although osteoporosis in children and adolescents is rare, its incidence in younger populations is showing an increasingly notable trend. The diagnostic criteria for osteoporosis in children and adolescents include a bone mineral density(BMD) Z-score of≤-2.0 accompanied by a significant fracture history, defined as two or more long bone fractures before the age of 10, three or more long bone fractures before the age of 19, or the presence of low-energy vertebral compression fractures even in the absence of low BMD. The genetic causes and underlying mechanisms of pediatric osteoporosis remain largely unknown, requiring further research to elucidate the molecular pathways involved. Such advances could help reduce the disease′s impact on growth and development and improve the quality of life in affected children and adolescents.
