A cohort study of the correlation between triglyceride-glucose index variability and new-onset hyperuricemia
10.3760/cma.j.cn311282-20240613-00259
- VernacularTitle:三酰甘油葡萄糖指数变异性与新发高尿酸血症相关性的队列研究
- Author:
Qiuyue JIA
1
;
Jingfeng CHEN
;
Youxiang WANG
;
Lin WANG
;
Suying DING
Author Information
1. 郑州大学公共卫生学院流行病学教研室，郑州 450001
- Publication Type:Journal Article
- Keywords:
Triglyceride-glucose index;
Variability;
Hyperuricemia;
Cohort study
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(2):99-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between triglyceride-glucose(TyG) index level, their variability, and the risk of incident hyperuricemia(HUA).Methods:A total of 1 583 cases with good compliance who underwent follow-up at the health examination center of a tertiary hospital physical in Zhengzhou were enrolled. The TyG index mean(TyG-mean) and variability indexes, including standard deviation(TyG-SD), coefficient of variation(TyG-CV), and adjusted standard deviation(adj-TyG-SD), were calculated based on TyG index values from three consecutive annual health check-ups. Cox proportional risk regression model was used to assess the relationship between the variability of TyG index and the risk of new-onset HUA; the dose-response relationship between different TyG indexes and HUA was examined using restricted cubic spline(RCS). Results:After a 3-year follow-up, 146 participants developed incident HUA. Both TyG-mean and TyG index variability indicators were significantly higher in the HUA group compared to the non-HUA group( P<0.05). After adjusting for multiple confounders, each standard deviation σincrease in TyG-SD, TyG-CV, and adj-TyG-SD was associated with a 1.23-fold(95% CI 1.06-1.43), 1.22-fold(95% CI 1.05-1.42), and 1.26-fold(95% CI 1.08-1.45) higher risk of incident HUA, respectively. RCS analysis revealed a nonlinear association between adj-TyG-SD and HUA risk( P<0.05), with a critical threshold of 0.55 at a hazard ratio( HR) of 1. Conclusions:Increased TyG index variability is associated with a higher risk of incident HUA, with adj-TyG-SD showing the strongest correlation with HUA risk.
