Interaction between triglyceride-glucose index and alkaline phosphatase on brachial-ankle pulse wave velocity in postmenopausal women
10.3760/cma.j.cn311282-20240521-00211
- VernacularTitle:三酰甘油葡萄糖指数及碱性磷酸酶对绝经后女性臂踝脉搏波传导速度的交互作用
- Author:
Bing JIA
1
;
Zhenhai SHEN
;
Peng YUAN
;
Liuyu WANG
;
Shaolei LI
;
Ping ZHANG
;
Hongwei LI
;
Yun LU
Author Information
1. 江苏省原子医学研究所附属江原医院内分泌科，无锡 214063
- Publication Type:Journal Article
- Keywords:
Triglyceride-glucose index;
Alkaline phosphatase;
Arterial stiffness;
Brachial and ankle pulse wave conduction velocity;
Postmenopausal women
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(2):93-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of triglyceride-glucose(TyG) index and alkaline phosphatase(ALP) on brachial-ankle pulse wave conduction velocity(baPWV) in postmenopausal women.Methods:A cross-sectional study was conducted, enrolling 3 483 postmenopausal women who underwent health checkup at Taihu Sanatorium in Jiangsu Province from March 2020 to June 2021. The physical activity, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), ALP, and baPWV were collected.Results:Age, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, and LDL-C levels were significantly lower in the normal baPWV group( n=1 971) than those in the elevated baPWV group( n=1 512; P<0.001). Logistic regression identified the TyG index( OR=1.75) and ALP level( OR=1.20) as independent risk factors for elevated baPWV( P<0.001), besides with age, body mass index, systolic blood pressure, diastolic blood pressure, and regular exercise. Individuals with both high TyG index and elevated ALP had a 2.51-fold higher risk of elevated baPWV(95% CI 2.01-3.14). Adjusted interaction measures(including age, body mass index, systolic blood pressure, diastolic blood pressure, and regular exercise) showed RERI=2.825(95% CI 1.255-3.905), AP=0.348(95% CI 0.180-0.875), and SI=1.657(95% CI 0.628-3.374). Conclusions:The TyG index and ALP levels are independent risk factors for elevated baPWV in postmenopausal women and exhibit an additive interaction effect on arterial stiffness in this population.
