Mechanistic and translational study of transketolase-regulated nucleoside metabolism and mitochondrial function in hepatocytes
10.3760/cma.j.cn311282-20241011-00461
- VernacularTitle:转酮醇酶调控肝细胞核苷代谢和线粒体功能的机制和应用研究
- Author:
Lingfeng TONG
1
;
Zhangbing CHEN
1
;
Xuemei TONG
1
Author Information
1. 上海交通大学医学院生物化学与分子细胞生物学系 200025
- Publication Type:Journal Article
- Keywords:
Transketolase;
Nucleoside metabolism;
Mitochondria;
Metabolic dysfuction-associated fatty liver disease
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews a study from Cell Metabolism, titled "Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity" [Tong L, Chen Z, Li Y, et al. Cell Metab. 2024, 36(5): 1013-1029.e5], and discusses its scientific implications. The study explores selective hepatic insulin resistance in metabolic dysfuction-associated fatty liver disease(MAFLD), where insulin stimulates lipid synthesis but not gluconeogenesis in resistant livers. It reveals the key role of transketolase(TKT) in MAFLD progression by disrupting pentose metabolism and nucleoside homeostasis, leading to inhibited mitochondrial activity. Targeting TKT with N-acetylgalactosamine-conjugated small interfering RNA(GalNAc-siTKT) improved metabolic dysfunction-associated steatohepatitis(MASH) and hepatic fibrosis.
