Correlation between psoas major index of diffuse large B-cell lymphoma patients and prognosis after R-CHOP chemotherapy
10.13929/j.issn.1003-3289.2025.07.019
- VernacularTitle:弥漫大B细胞淋巴瘤患者腰大肌指数与其经R-CHOP化疗后预后的相关性
- Author:
Wei JIANG
1
;
Ke ZHAO
;
Cuiping BAO
;
Yongchun JIA
;
Zugui LI
;
Wenyan ZHANG
;
Liang XU
Author Information
1. 天津市人民医院/南开大学第一附属医院核医学科,天津 300121
- Publication Type:Journal Article
- Keywords:
lymphoma,large B-cell,diffuse;
psoas muscles;
sarcopenia;
prognosis;
tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2025;41(7):1125-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between psoas major index(PMI)in patients with diffuse large B-cell lymphoma(DLBCL)and prognosis after rituximab,cyclophosphamide,doxorubicin,vincristine,prednisone(R-CHOP)chemotherapy.Methods Totally 148 DLBCL patients who received R-CHOP chemotherapy were retrospectively enrolled.Based on axis CT image at L3 vertebral transverse process,bilateral psoas muscles were delineated,and PMI was calculated.Then the patients were divided into muscle reduction group(≤lower quartile,n=37)and control group(＞lower quartile,n=111)according to the lower quartile of PMI.Clinical and imaging data were compared between groups,and the correlations of PMI with the above indexes were analyzed.The impact factors of prognosis of DLBCL were observed.Results Significant differences of body mass index(BMI),Eastern Cooperative Oncology Group(ECOG)score,international prognostic index(IPI),the proportion of B symptoms,mortality rate,3-year survival rate,β2-microglobulin,hemoglobin,albumin and PMI were found between groups(all P＜0.05).PMI of DLBCL patient was negatively correlated with age,ECOG score,IPI,β2-microglobulin and lactate dehydrogenase(LDH)(r=—0.126,-0.225,—0.262,—0.232,—0.229,all P＜0.05),but positively correlated with BMI and hemoglobin(r=0.282,0.376,both P＜0.05).The age,ECOG score,IPI and PMI were all independent impact factors of overall survival in DLBCL patients(all P＜0.05).Conclusion PMI was an independent impact factor of prognosis of DLBCL after R-CHOP chemotherapy.
