Correlation between adiponectin/leptin ratio and heart failure with preserved ejection fraction
10.3969/j.issn.1009-0126.2025.09.015
- VernacularTitle:脂联素/瘦素比值与射血分数保留的心力衰竭的相关性研究
- Author:
Cong SUN
1
;
Tongjian ZHU
1
;
Ming LU
1
;
Caibo LI
1
;
Jian ZHANG
1
;
Bin LI
1
Author Information
1. 441000 湖北文理学院附属医院襄阳市中心医院心血管内科
- Publication Type:Journal Article
- Keywords:
heart failure;
adipokines;
adiponectin;
leptin
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1203-1207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between adiponectin/leptin(Adpn/Lep)ratio and risk of heart failure with preserved ejection fraction(HFpEF).Methods A total of 84 hospi-talized HFpEF patients(HFpEF group)and 84 age-and sex-matched non-heart failure patients(control group)admitted in Xiangyang Central Hospital between October 2023 and April 2024 were recruited in this study.Serum Adpn and Lep levels were measured using ELISA.Spearman correlation analysis was applied to assess the relationship between the Adpn/Lep ratio and other HFpEF-related parameters.Univariate and multivariate logistic regression analyses were per-formed to identify risk factors for HFpEF.ROC curve was plotted to evaluate the auxiliary diag-nostic value of the Adpn/Lep ratio for HFpEF.Results The HFpEF group exhibited significantly higher leptin level,but lower Adpn level and Adpn/Lep ratio when compared with the control group(P＜0.01).Spearman correlation analysis revealed that Adpn/Lep ratio was negatively cor-related with N-terminal fragment of brain natriuretic peptide prohormone and left atrial diameter(r=-0.476,r=-0.328,P＜0.01)in HFpEF patients.Multivariate logistic regression analysis identified the Adpn/Lep ratio as an independent risk factor for HFpEF(P＜0.01).ROC curve analysis demonstrated that the AUC value of Adpn/Lep ratio,Adpn,and Lep in predicting HFpEF was 0.818(95％CI:0.747-0.888),0.639(95％CI:0.544-0.734)and 0.638(95％CI:0.550-0.726),respectively,and the ratio obtained better predictive performance than the two indicators(P＜0.01).Conclusion Adpn/Lep ratio is associated with HFpEF.Lower Adpn/Lep ratio has good auxiliary diagnostic value for HFpEF.The ratio can better predict the occurrence of HFpEF than Adpn and Lep alone.
