Relationship between inflammatory indexes and occurrence of acute kidney injury in elderly patients with coronary heart disease after PCI
10.3969/j.issn.1009-0126.2025.09.017
- VernacularTitle:老年冠心病患者炎症指标与经皮冠状动脉介入治疗术后急性肾损伤发生的关系研究
- Author:
Yu WANG
1
;
Zeyan LIU
;
Qian TANG
Author Information
1. 230000 合肥,安徽医科大学第二附属医院肾脏内科
- Publication Type:Journal Article
- Keywords:
coronary disease;
acute kidney injury;
carrier proteins;
lymphocytes
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1212-1215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of changes in neutrophil gelatinase associated lipocalin(NGAL)and neutrophil to lymphocyte ratio(NLR)with risk of acute kidney injury(AKI)in elderly patients with coronary heart disease(CHD)after PCI.Methods A total of 150 elderly CHD patients admitted in our hospital from September 2020 to September 2024 were ret-rospectively included,and according to whether AKI occurred after PCI,they were divided into AKI group(46 cases)and non-AKI group(104 cases).NGAL and NLR were detected,and the relationship between their changes and risk of AKI after PCI was analyzed.Results The AKI group had significantly advanced age,higher serum creatinine(sCr)level,higher contrast agent dose,and elevated NGAL and NLR levels after PCI than the non-AKI group(P＜0.01).The NGAL and NLR were positively correlated with sCr level(r=0.272,r=0.370,P＜0.01).The NGAL,NLR,age and contrast agent dose were risk factors for AKI after PCI(P＜0.05,P＜0.01).ROC curve analysis revealed that the AUC value of NGAL and NLR in evaluating the risk of AKI after PCI was 0.844(95％CI:0.774-0.913,P=0.000)and 0.854(95％CI:0.779-0.929,P=0.000),respectively.Conclusion Elevated NGAL and NLR levels are related to the risk of AKI in elderly CHD patients after PCI,and they are helpful for early clinical identification.
