Independent component analysis for assessing functional abnormalities in frontoparietal attention network of patients with traumatic brain injury and analyzing neural mechanism of attention disorders
10.13929/j.issn.1003-3289.2025.07.007
- VernacularTitle:基于独立成分分析评估颅脑损伤患者额顶注意网络功能异常及注意障碍神经机制
- Author:
Gaiyun ZHANG
1
;
Xingxing JIN
1
;
Hongxia WANG
1
;
Wangyi LIU
1
;
Jinhui DUAN
1
;
Ruifang YAN
1
Author Information
1. 新乡医学院第一附属医院磁共振科,河南新乡 453100
- Publication Type:Journal Article
- Keywords:
brain injuries;
magnetic resonance imaging;
neural networks,computer;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(7):1062-1067
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess functional abnormalities in frontoparietal attention network of patients with traumatic brain injury(TBI),and to analyze neural mechanism of its attention disorders based on independent component analysis(ICA).Methods Totally 84 TBI patients were prospectively enrolled and divided into mild(n=33),moderate(n=27)and severe TBI groups(n=24)according to symptoms,non-contrast enhanced MRI findings,Glasgow coma scale(GCS)and Mayo craniocerebral trauma grading criteria.ICA was used to extract and analyze the optimal independent components(IC)of the dorsal attention network(DAN)and ventral attention network(VAN).Multiple linear regression analyses were performed to explore the correlations of functional connectivity(FC)of brain regions being significantly different among groups within attention network and the scores of trail making test A/B(TMT-A/B).Results Compared with control group and mild TBI group,spatial distribution of DAN(especially bilateral frontal eye field[FEF])in moderate and severe TBI groups were significantly smaller,the clusters tended to be discrete,and the intensity were significantly weakened.The right temporal parietal junction(TPJ)and right ventral frontal cortex(VFC)of VAN in control group,mild and moderate TBI groups were significantly affected,and VFC connection strength was the highest in severe TBI group.FC intensity in right VFC of TBI patients was positively correlated with TMT-A score(r=0.654,P＜0.001),which in left FEF was negatively correlated with TMT-B score(r=—0.383,P＜0.001).Conclusion FC of frontoparietal attention network was abnormal in TBI patients,which might be neural mechanism for its attention behavior disorders.
