Safety and efficacy of remote ischemic conditioning for cerebral hemorrhage in the elderly
10.3969/j.issn.1009-0126.2024.12.017
- VernacularTitle:远隔缺血适应治疗老年脑出血的安全性和疗效研究
- Author:
Meng LIN
1
;
Jian DING
;
Xuegan LIAN
;
Song YANG
Author Information
1. 213003 常州市第一人民医院(苏州大学附属第三医院)神经内科;泰州市第二人民医院神经内科
- Publication Type:Journal Article
- Keywords:
cerebral hemorrhage;
safety;
prognosis;
remote ischemic conditioning
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(12):1463-1466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of RIC in the treatment of elderly patients with ICH.Methods A prospective trial was conducted on 40 elderly patients with spontaneous ICH admitted to our hospital from January to August 2024.They were randomly assigned to a RIC group(20 cases,conventional treatment combined with RIC intervention)and a control group(20 cases,conventional treatment combined with sham intervention).Hematoma absorption,prog-nosis,and adverse reactions were compared between the two groups.Results The hematoma ab-sorption rate at 7 d after admission was(44.80±14.40)％in the RIC group,which was higher than that of the control group(38.50±20.80)％,though no statistical difference was seen be-tween the two groups(P＞0.05).There was no significant difference in the NIHSS score on the 7th day between the two groups(P＞0.05).At 30 d,the proportion of the patients with mRS ≤2 was 50.0％in the RIC group and 35.0％in the control group,but there was no obvious difference between them(P＞0.05).The proportions of patients with cuff marks and skin petechiae were no-tably higher in the RIC group than the control group(40.0％vs 0.0％,P＜0.01;45.0％vs 0.0％,P＜0.01),but no skin ecchymosis or serious adverse events were observed in both groups.Conclu-sion RIC treatment shows good safety and tolerability in treatment of spontaneous ICH in elder-ly patients.Although it has a potential trend towards promoting hematoma absorption and neuro-logic improvement,its short-term therapeutic effect is not significant.
