Correlation of peripheral blood eosinophils with left ventricular hypertrophy in elderly patients with hypertension
10.3969/j.issn.1009-0126.2024.12.003
- VernacularTitle:外周血嗜酸性粒细胞与老年高血压合并左心室肥厚的相关性研究
- Author:
Yinfeng GAO
1
;
Chen ZHANG
1
;
Xiaoqing XI
1
;
Junhong MENG
1
;
Jianting HUO
1
;
Wenli LUO
1
Author Information
1. 832000 石河子大学第一附属医院全科医学科
- Publication Type:Journal Article
- Keywords:
hypertension;
correlation of data;
eosinophil;
left ventricular hypertrophy
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(12):1396-1400
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between peripheral blood eosinophil(EOS)and left ventricular hypertrophy(LVH)in elderly patients with hypertension.Methods A retrospec-tive cross-section analysis was conducted on 711 elderly hypertensive patients admitted to our de-partment from January to December 2023.According to their EOS count,they were divided into Group 1(＜100×106/L),Group 2[(100-190)× 106/L]and Group 3(＞190 × 106/L).The gen-eral clinical data,biochemical indicators,and echocardiographic parameters were compared among the three groups.The correlation between EOS and each indicator was analyzed by using Spearman correlation analysis.Logistic regression analysis was employed to identify the influential factors for hypertension complicated with LVH.Results Smoking history,TG and UA levels,and lymphocyte counts were gradually increased,while HDL-C level was gradually decreased in the three groups with the increment of EOS count(P＜0.05,P＜0.01).The proportions of usingβ-blockers,calcium channel blockers and statins were gradually increased in the three groups(P＜0.05,P＜0.01),so were the values of LVM,LVMI,IVST,LVEDD and LVPWT in them(P＜0.01).EOS count was positively correlated with the values of LVM,LVMI,IVST,LVEDD and LVPWT,smoking history,TG and UA levels,WBC,lymphocyte and monocyte counts,and ratios of using β-blockers,calcium channel blockers and statins,but negatively with HDL-C level(P＜0.05,P＜0.01).Binary logistic regression analysis showed that female and HDL-C were protective factors for LVH in hypertensive patients,while age and EOS count were risk factors(OR=0.149,95％CI:0.096-0.230;OR=0.632,95％CI:0.399-0.999;OR=1.034,95％CI:1.007-1.062;OR=1.956,95％CI:1.446-2.645).Conclusion In elderly hypertensive patients with LVH,female and HDL-C are the protective factors,while age and EOS are the risk factors.EOS has a certain correlation with the occurrence of LVH in elderly hypertensive patients.
