Clinical effects of Xiaopi Decoction on patients with chronic atrophic gastritis of Spleen-Stomach Weakness Pattern
10.3969/j.issn.1001-1528.2024.10.016
- VernacularTitle:消痞汤对脾胃虚弱证慢性萎缩性胃炎患者的临床疗效
- Author:
Shuo CHEN
1
;
Jiang-hui LI
;
Jia-hui HONG
;
Su LI
;
Dong-ping WU
;
Mei-fang CHEN
;
Jun-ling XIE
;
Xin-yue GU
;
Shao-dong CHEN
;
Qiu-fang LIN
Author Information
1. 福建省南平市人民医院消化科,福建 南平353000
- Publication Type:Journal Article
- Keywords:
Xiaopi Decoction;
conventional treatment;
chronic atrophic gastritis;
Spleen-Stomach Weakness
- From:
Chinese Traditional Patent Medicine
2024;46(10):3288-3292
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Xiaopi Decoction on patients with chronic atrophic gastritis of Spleen-Stomach Weakness Pattern.METHODS Ninety-seven patients were randomly assigned into control group ( 48 cases ) for 4-week intervention of conventional treatment,Mosapride Citrate Tablets and Pancreatin Enteric-coated Tablets,and observation group ( 49 cases ) for 4-week intervention of both Xiaopi Decoction and conventional treatment.The changes in clinical effects,brain-intestinal peptide indices ( CGRP,5-HT,SP,NPY),Hp negative conversion rate,gastric juice components (free acid,pepsin,nitrite,total acid),gastrointestinal hormones ( GAS,MLT,SS),gastric mucosa pathological scores and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group (P<0.05).After the treatment,the two groups displayed increased brain-intestinal peptide indices,NPY,SS,free acid,pepsin,total acid ( P<0.05 ),and decreased MLT,nitrite,.scores for mucosal inflammation and mucosal atrophy ( P<0.05),especially for the observation group ( P<0.05).No significant difference in incidence of adverse reactions was found between the two groups (P>0.05).CONCLUSION For the patients with chronic atrophic gastritis of Spleen-Stomach Weakness Pattern,Xiaopi Decoction can safely and effectively reduce the inflammation and atrophy of gastric mucosa,and improve gastric juice components and gastrointestinal hormones,whose mechanism may contribute to the regulation of brain-intestinal axis.
