Clinical effects of Compound Shengdi Mixture on patients with mild to moderate systemic lupus erythematosus
10.3969/j.issn.1001-1528.2024.12.014
- VernacularTitle:复方生地合剂对轻中度系统性红斑狼疮患者的临床疗效
- Author:
Xing-yu XU
1
;
Na ZHANG
1
;
Bo YU
1
;
Bei-bei SUN
1
;
Hua-yan TANG
1
Author Information
1. 上海中医药大学附属市中医医院风湿病科,上海200071
- Publication Type:Journal Article
- Keywords:
Compound Shengdi Mixture;
basic treatment;
mild to moderate systemic lupus erythematosus
- From:
Chinese Traditional Patent Medicine
2024;46(12):3992-3996
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Compound Shengdi Mixture on patients with mild to moderate systemic lupus erythematosus.METHODS One hundred and twenty patients were randomly assigned into control group (60 cases) for 12-week intervention of basic treatment,and observation group (60 cases) for 12-week intervention of both Compound Shengdi Mixture and basic treatment.The changes in clinical effects,SLEDAI score,TCM syndrome score,prednisone dose,laboratory indices (WBC,HGB,PLT,anti-ds-DNA,ANA titer,ESR,IL-6,TNF-α,C3,C4,IgG),24 h PRO and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group (P<0.05).After the treatment,the two groups displayed decreased SLEDAI score,TCM syndrome score,prednisone dose,IL-6,TNF-α(P<0.05,P<0.01),especially for the observation group (P<0.05,P<0.01);the observation group displayed decreased anti-ds-DNA,ANA titer,24 h PRO (P<0.05,P<0.01),along with increased HGB (P<0.01).No significant differences in WBC,PLT,ESR,C4,C3,IgG and incidence of adverse reactions were found between the two groups (P>0.05).CONCLUSION For the patients with mild to moderate systemic lupus erythematosus,Compound Shengdi Mixture can safely and effectively inhibit immunological inflammatory responses,improve clinical symptoms and alleviate disease activity.
