Chemical constituents from Jiannaoning Mixture and their antioxidant activities
10.3969/j.issn.1001-1528.2024.12.019
- VernacularTitle:健脑宁合剂化学成分及其抗氧化活性研究
- Author:
Ji-yong FU
1
;
Jing-yi WANG
;
Jun-dong YU
;
Yan-xu ZHANG
;
Lü-feng ZHANG
;
Guo-fu ZHU
;
Ying-chun WU
Author Information
1. 驻马店市第二人民医院,河南 驻马店463002
- Publication Type:Journal Article
- Keywords:
Jiannaoning Mixture;
chemical constituents;
isolation and identification;
antioxidant activites;
traditional Chinese medicine compound
- From:
Chinese Traditional Patent Medicine
2024;46(12):4020-4028
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Jiannaoning Mixture and their antioxidant activities.METHODS The extract was isolated and purified by silica gel,ODS,MCI,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The antioxidant activities were studied by superoxide dismutase activity test.RESULTS Twenty compounds were isolated and identified as erythro-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-n-butetheryl-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (1),threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-n-butetheryl-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (2),5-hydroxy methylfurfural (3),syringin (4),benzyl-β-D-glucopyranoside (5),spinosyn (6),cordifolioidyne A (7),adenosine (8),jujubosides A (9),jujubosides B (10),salvianolic acid B (11),methyl 3,4-dihydroxy-phenyl lactate (12),methylophiopogonanone A (13),methylophiopogonanone B (14),tanshinone ⅡA (15),ethylparaben (16),triallyl isocyanurate (17),betulinic acid (18),diosgenin (19),4-(9H-β-carbolin-1-yl)-4-oxobut-2-enoic acid methyl ester (20).The IC50 values of compounds 7,11 and 19 were (8.52±1.13),(17.10±2.89),(11.45±1.31) μmol/L,respectively.CONCLUSION Compounds1-2 are new neolignans.Compounds3-5,8,16-17,20 are first isolated from the single ingredient of this formula.Compounds 7,11,17 have antioxidant activities.
