Clinical significance of changes in serum complement C1q/ tumor necrosis factor-associated protein 3 levels in patients with rheumatoid arthritis
10.3760/cma.j.cn141217-20240528-00170
- VernacularTitle:血清补体C1q/肿瘤坏死因子相关蛋白3水平变化在类风湿关节炎患者中的临床意义
- Author:
Ting ZENG
1
;
Caiwen WEI
;
Weixiang CHEN
;
Lihua GU
;
Yue QIAN
;
Xinfeng ZHAO
;
Yan SHEN
Author Information
1. 上海健康医学院附属崇明医院（上海新华医院崇明分院）全科医学科，上海 202150
- Publication Type:Journal Article
- Keywords:
Arthritis, rheumatoid;
Disease activity;
Atherosclerosis;
C1q/tumour necrosis factor-related protein-3
- From:
Chinese Journal of Rheumatology
2025;29(3):197-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of serum complement C1q/tumor necrosis factor-associated protein 3 (CTRP3) in patients with rheumatoid arthritis (RA) and its clinical significance.Methods:A total of 60 RA patients admitted to Chongming Hospital affiliated to Shanghai University of Medicine & Health Sciences (Chongming Branch of Xinhua Hospital) from January 2023 to February 2024 were collected.They were divided into a plaque group (38 cases) and a plaque free group (22 cases) according to the results of carotid intima-media thickness (cIMT) by carotid artery ultrasonography. ESR, CRP, blood lipid, HOMA-IR, RF, CCP antibody and CTRP3 levels were detected, and the relationship between CTRP3 levels and disease activity and atherosclerosis in RA patients was analyzed. The statistical analysis was carried out with independent t-test, analysis of variance, Pearson correlation analysis and logistic regression. Results:Serum CTRP3 level in RA patients was lower than that in healthy control group [(116±44)ng/ml and (184±63)ng/ml, t=-6.54, P=0.004]. The CTRP3 level in RA group with plaque was lower than that in RA group without plaque [(98±28) ng/ml and (123±38)ng/ml, t=-5.57, P=0.008]. Serum CTRP3 levels in RA patients were correlated with LDL-C ( r=-0.68, P=0.011), HOMA-IR ( r=-0.74, P=0.001), RF ( r=-0.46, P=0.042), anti-CCP antibody( r=-0.54, P=0.037), DAS28 ( r=-0.66, P=0.024) were negatively correlated with cIMT ( r=-0.76, P=0.001), and positively correlated with DMARDs duration ( r=0.51, P=0.040) and flow-mediated di latatiton ( r=0.70, P=0.004). The CTRP3 level [( OR(95% CI)=0.683(0.355, 0.807), P=0.023] was an independent correlation factor affecting cIMT. Conclusion:CTRP3 level in RA patients is significantly lower than that in healthy control group, and is negatively correlated with insulin resistance, autoantibody level and disease activity, and has a protective effect on early atherosclerosis in RA patients.
