Drug fever induced by apatinib mesylate tablets

VernacularTitle:甲磺酸阿帕替尼片致药物热
Author: Honglin XUE ¹ ; Yali TAN ; Wen LIANG ; Yan FEI
Author Information

1. 解放军第一七五医院/厦门大学附属东南医院药学科,福建漳州,363000
Publication Type:Journal Article
Keywords: Vascular endothelial growth factor receptor-2; Antineoplastic agents; Fever
From: Adverse Drug Reactions Journal 2018;20(5):390-392
CountryChina
Language:Chinese
Abstract: A 68-year-old male patient with liver metastases from colon cancer received apatinib mesylate tablets 500 mg orally once daily after the hepatic arterial chemoembolization.On day 3 after the medication,the patient had a fever of 39 ℃ with fear of cold,and his proportion of neutrophils,C reactive protein,and procalcitonin levels slightly increased without any definite focus of infection.It was considered that the drug fever was related to apatinib mesylate tablets.Apatinib mesylate tablets were discontinued and anti-infection treatments were given.Ten days later,the patient's body temperature returned to normal.Apatinib mesylate tablets were given again for the cancer but the patient had a fever again 3 days later.Apatinib mesylate tablets were stopped again,and then celecoxib capsules were given orally along with tepid sponge bathing to reduce fever.The patient's body temperature returned to normal on day 3 after the drug withdrawal.