Toxic epidermal necrolysis caused by calcium dobesilate capsules:report of 2 cases
10.3760/cma.j.issn.1008-5734.2018.03.014
- VernacularTitle:羟苯磺酸钙胶囊致中毒性表皮坏死松解症2例
- Author:
Tingting GAO
1
;
Li QIN
1
;
Xiaoyong ZHOU
1
Author Information
1. 430000,武汉市第一医院皮肤科
- Publication Type:Journal Article
- Keywords:
Calcium dobesilate;
Epidermal necrolysis,toxic
- From:
Adverse Drug Reactions Journal
2018;20(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Two female patients (patient 1,63 years old;patient 2,51 years old)with hypertension and chronic renal insufficiency received calcium dobesilate capsules 0.5 g thrice daily. Patient 1 developed red rash on her left upper limb,accompanied by high fever 15 days after medication. Patient 2 developed red rash on her trunk and both thighs,accompanied by cough and high fever 20 days after medication. They developed rash all over the body 1 day (patient 1)and 3 days (patient 2 ),respectively after the rash occurrence,ulceration on oral mucosa,binoculus,and pudendum 3 days (patient 1)and 9 days (patient 2),respectively after the rash occurrence. They were diagnosed as toxic epidermal necrolysis due to calcium dobesilate capsules. Calcium dobesilate capsules were stopped, and glucocorticoid, human immune globulin,supplement of potassium and calcium,etc. were given. The mucosal erosions were healed or improved on day 13 (patient 1)and 18 (patient 2)of treatments,respectively. The rash faded after 16 days (patient 1)and 25 days (patient 2)of treatments,respectively.
