Research progress of ferroptosis in sepsis
10.3760/cma.j.issn.1673-4912.2025.08.011
- VernacularTitle:铁死亡在脓毒症中的研究进展
- Author:
Xidan HU
1
;
Xiaoqing JING
1
Author Information
1. 承德医学院附属医院小儿内科 067000
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Sepsis;
Organ injury
- From:
Chinese Pediatric Emergency Medicine
2025;32(8):614-618
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by the host's dysfunctional response to infection.Sepsis involves complex immune and inflammatory responses that lead to organ microcirculation dysfunction，cellular mitochondrial dysfunction，and induced cell death.Ferroptosis is a newly identified form of cell death characterized by iron-dependent accumulation of peroxides. It is widely activated in sepsis-induced multiple organ injury. The underlying mechanisms involve lipid peroxidation, mitochondrial damage, glutathione peroxidase 4 inhibition, iron metabolism dysregulation, p53 gene regulation, and dysfunction of the Xc-antiporter system. This review focused on the relationship between ferroptosis,its key mechanisms and sepsis-related organ injury, providing new insights for potential therapeutic strategies.
